Endocrine Abstracts

The syndrome of inappropriate antidiuresis (SIAD) is characterised by plasma hyponatraemia and plasma hypoosmolality with a high urinary sodium in a clinically euvolaemic patient. We describe only the second reported case of SIAD due to carboplatin administration, with consequent acute severe hyponatraemia.A 61-year-old lady with no background history of note received neoadjuvant carboplatin and paclitaxel for stage III ovarian carcinoma. Five days after...

The IGFs are present ubiquitously at very high levels throughout the body and affect virtually every aspect of cell function. These high levels are maintained due to their association with 6 distinct binding proteins (IGFBP-1 to -6) which specifically bind IGFs (but not insulin). The IGFs are not stored within any cells but are stored in the circulation due to their binding to IGFBP-3 which then results in its association with a large glycoprotein, the acid labile subunit (ALS...

Aspergillus infection of the paranasal sinuses is an unusual phenomenon but is the commonest fungal infection of these structures. A 67 year-old man was admitted with six months' lethargy, vomiting, and weight loss. Past history included sinusitis. On examination he was well but dehydrated. BP 100/60. No other abnormal findings. Routine blood results were normal.A provisional diagnosis of upper GI malignancy was made but gastroscopy was normal. The thyro...

Disruption of the normal cell cycle is one of the most frequent alterations in tumour cells, contributing to uncontrolled cell proliferation during tumour development. The CDK inhibitor p27 plays a pivotal role in controlling cell proliferation during development and tumourigenesis, and has been implicated in tumorigenesis in rats. Previous studies have demonstrated changes in p27 protein expression, in human pituitary tumours,especially in corticotroph tumours, where p27 prot...

The reported incidence of thyroid dysfunction associated with interferon-α (IFNα) treatment for hepatitis C infection varies widely between countries.1 To our knowledge the spectrum of thyroid dysfunction in IFNα-treated Irish patients has not been described outside of an anti-D-related, hepatitis C-infected cohort.We reviewed thyroid function tests (TFTs) from all Hepatitis C positive patients undergoing IFNα treatment ove...

PCOS is associated with increased biochemical risk markers for cardiovascular disease, particularly low HDL cholesterol and increased triglycerides. There is accelerated progression to type 2 diabetes and hypertension in middle age. These biochemical abnormalities associate with insulin resistance which is present to a greater extent than can be explained by obesity alone. Notwithstanding, hard endpoint data in terms of increased cardiovascular mortality remains elusive. Infla...

PCOS is associated with increased biochemical risk markers for cardiovascular disease, particularly low HDL cholesterol and increased triglycerides. There is accelerated progression to type 2 diabetes and hypertension in middle age. These biochemical abnormalities associate with insulin resistance which is present to a greater extent than can be explained by obesity alone. Notwithstanding, hard endpoint data in terms of increased cardiovascular mortality remains elusive. Infla...

TSH activates the TSH receptor (TSHR) thereby stimulating the function of thyroid follicular cells (thyrocytes) leading to biosynthesis and secretion of thyroid hormones. Because TSHR is involved in several thyroid pathologies there is a strong rationale for the design of small molecule ‘drug-like’ ligands (SMLs).rhTSH (ThyrogenR) has been used in the follow-up of patients with thyroid cancer to increase the sensitivity for detection...

Clinical features associated with PCOS include obesity, hirsutism or acne, cycle abnormalities and infertility. Therefore, depending on the primary complaint these patients visit different medical specialists such as general practitioner, pediatrician, dermatologist, medical endocrinologist and gynecologist. The variability in primary complaint asks for different approaches in the work-up of these patients. Hence, doctors usually see just a proportion of the overall spectrum o...

Objective: Assessment of the accuracy of physical examination performed by thyroid surgery team doctors at thyroid clinic.Method: Random review of 120 new referrals to thyroid clinic, with review of clinical findings on physical examination on first attendance to clinic and compare the clinical findings with subsequent ultrasound scan findings.Results: Of total number of 120 patients, 63 had solitary nodule on physical examination,...